Aminopurvalanol A
CAS No. 220792-57-4
Aminopurvalanol A( —— )
Catalog No. M27529 CAS No. 220792-57-4
Aminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1, Cyclin E/cdk2, and P35/cdk5 with IC50 of 33 nM, 33 nM, 28 nM and 20 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 53 | In Stock |
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5MG | 87 | In Stock |
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10MG | 147 | In Stock |
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25MG | 290 | In Stock |
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50MG | 447 | In Stock |
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100MG | 651 | In Stock |
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500MG | 1368 | In Stock |
|
1G | Get Quote | In Stock |
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Biological Information
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Product NameAminopurvalanol A
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NoteResearch use only, not for human use.
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Brief DescriptionAminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1, Cyclin E/cdk2, and P35/cdk5 with IC50 of 33 nM, 33 nM, 28 nM and 20 nM, respectively.
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DescriptionAminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1, Cyclin E/cdk2, and P35/cdk5 with IC50 of 33 nM, 33 nM, 28 nM and 20 nM, respectively.
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In VitroAminopurvalanol A (5 and 40 μM; 8 hours) inhibits cell growth primarily by arresting the cells in the G2 phase of the cell cycle and, at higher concentration, triggering apoptosis.:Cell Cycle Analysis Cell Line:Human U937 leukemic cells Concentration:5 and 40 μM Incubation Time:8 hours Result:Increased the number of cells with a 4N DNA content as early as 8 h after the beginning of treatment at 5 μM. 40 μM led to cellular fragmentation and cells with an irregular DNA distribution, characteristic of apoptotic cell populations.Apoptosis Analysis Cell Line:Human U937 leukemic cells Concentration:5 and 40 μM Incubation Time:8 hours Result:40 μM Aminopurvalanol A led to apoptosis rather than after the beginning of treatment at 5 μM.
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetCDK
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RecptorGap Junction Protein|FTO
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Research Area——
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Indication——
Chemical Information
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CAS Number220792-57-4
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Formula Weight403.91
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Molecular FormulaC19H26ClN7O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (247.58 mM)
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SMILESCC(C)[C@H](CO)Nc(nc1Nc2cc(N)cc(Cl)c2)nc2c1ncn2C(C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Eleftheriou CG, et al. Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopicexpression of human rod opsin. Mol Vis. 2017 Jun 16;23:334-345. eCollection 2017.
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